In vitro dissolution and physicochemical characterizations of novel PVP-based solid dispersions containing valsartan prepared by a freeze-drying method
Wei-Juan Xu, Yan Liu, Li-Li Shi, Jing-Hao Cui, Qing-Ri Cao
Valsartan (VAL) shows poor oral bioavailability mainly as a result of its low water solubility at low pH
Keywords
Valsartan
solid dispersion
freeze-drying
dissolution
physicochemical property.
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In vitro dissolution and physicochemical characterizations of novel PVP-based solid dispersions containing valsartan prepared by a freeze-drying method | PJPS