Screening of clonidine effect on brain acetylcholine content, anticonvulsant and local anaesthetic properties

Clonidine, a potent centrally acting antihypertensive drug was screened for effect on “free” and “bound” acetylcholine (Ach) in brain of morphine dependent and morphine withdrawal rats, anticonvulsant activity and morphine withdrawal rats, antconvulsant activity and local anaesthetic activity