Elizabeth Ortega Molina, Maria Josefa Bernad Bernad, Jesus Gracia Mora, Dinorah Vargas Estrada, Luis Ocampo Camberos
Tramadol reaches therapeutic plasma concentrations in a time interval of 0.5 to 1.7 hours, so it is necessary to dose 4 times/day
Tramadol
release
polymer matrix
in vitro
spectrophotometer
membrane
concentrations