Apocynin attenuates methotrexate-induced mucositis by regulating NF-?B, PPAR-? and Bax/Bcl-2/Puma signals Page No: 457-466

By: Manal MS Mansoury, Haifa Almukadi, Arwa M Turkistani, Hala AH Khattab, Soad S Ali, Emad HM Hassanein, Bassam A Alahmadi, Soad Al-Jaouni, Nagla A El-Shitany

Keywords: Methotrexate, apocynin, apoptosis, NF-?B, PPAR-?

DOI : 10.36721/PJPS.2023.36.2.REG.457-466.1

Abstract: Oxidative stress, inflammation, and apoptosis are the primary inducers of Methotrexate (MTX)-induced mucositis

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