By: Yuanyuan Wu, Lanlan Wu, Yifang Ma, Jianguo Li, Xiangyang Song, Jun Li, Xiaofeng Song
Keywords: Mixed hemorrhoids, Bixie, multimodal analgesia, Chinese and Western medicine therapy, postoperative pain, wound healing
DOI : 10.36721/PJPS.2024.37.4.REG.819-827.1
Abstract: We were to explore the effect of Bixie combined with perioperative multimodal analgesia management on postoperative pain and wound healing of mixed hemorrhoids. A total of 240 patients with mixed hemorrhoids in this hospital from June 2022 to September 2023 were chosen, with 120 in the control group receiving perioperative multimodal analgesia management and 120 in the observation group receiving Bixie combined with perioperative multimodal analgesia management. The results showed that compared with the control group, the observation group had lower visual analogue scale (VAS) scores at 1, 3, 5 and 7 days after the surgery; the 5-hydroxytryptamine (5-HT), prostaglandin E2 (PGE2), nitric oxide (NO), interleukin-2 (IL-2), interleukin-6 (IL-6), and tumor necrosis factor-? (TNF-?) of the observation group at 24 hours and 72 hours after the surgery were lower; the vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), platelet-derived growth factor (PDGF), and wound healing rate of the observation group at 7 days after the surgery were higher; the total effective rate of the observation group was higher. Therefore, combining Bixie with perioperative multimodal analgesia management could improve postoperative pain, decrease inflammatory factor levels, promote angiogenesis, and accelerate wound healing in patients with mixed hemorrhoids.
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