Pakistan Journal of Pharmaceutical Sciences

Abstract: To investigate the synergistic effects of Poly-L-Lactic Acid (PLLA) and Retinoic Acid (RA) on age-related skin relaxation in the treatment of facial rejuvenation. 120 patients received facial rejuvenation treatment at Sin-An Cosmetic Clinic Hospital from April 2022 to August 2023 were divided into control group (n=42) and observation group (n=78). Both groups were treated with RA and observation group was added with PLLA. The outer corner wrinkles and lower eyelid wrinkles, nasolabial wrinkles, self-perception ratings of skin effects and adverse reactions incidence were compared between both groups. After treatment, the total improvement rates of outer eye corners, lower eyelid wrinkles and nasolabial folds, the improvement rate of the overall aesthetics of the mid-face, the scores of skin elasticity, water content, skin colour, pores and other skin conditions of the observation group were significantly higher than the control group and the scores of oil secretion and dark spots were significantly lower than the control group (P<0.05). The incidence of adverse reactions in the observation group was lower than the control group, but the difference was not significant (P>0.05). Combined treatment can improve patients' skin condition and promote facial rejuvenation, which has high clinical application value.