By: Lin Liu, Li Ma, Yan Wang, Yan Chen, Ying Zhang
Keywords: Baofukang suppository; Cervical cancer; Cytokine; Epithelial mesenchymal transformation; Immune function; Patient safety
DOI : 10.36721/PJPS.2025.38.6.REG.12345.1
Abstract: Cervical cancer, a prevalent female malignancy, is treated with surgery, radiotherapy, chemotherapy, immunotherapy and targeted therapy. Yet, prognosis remains influenced by multiple factors. Epithelial-mesenchymal transformation (EMT) is an important link in the malignant progression of tumor cells and has an important impact on the progression and prognosis of cervical cancer. This study aimed to analyze effect of Baofukang suppository on the related indexes of EMT of tumor cells in cervical cancer patients. Eighty patients with cervical cancer received in The First Affiliated Hospital of Anhui Medical University from March 2020 to March 2022 were randomized into a control group (chemotherapy alone, n=40) and a study group (chemotherapy + Baofukang, n=40). Post-treatment, the study group showed significantly lower mRNA levels of EMT markers Vimentin and N-cadherin, and higher E-cadherin and ?-catenin (p<0.05). Additionally, interleukin-6 (IL-6) decreased while interleukin-2 (IL-2) and interferon-? (INF-?) increased (p<0.05). Immune function improved, with higher CD3+, CD4+ and CD4+/CD8+ ratios, and lower CD8+ (p<0.05). The adverse reactions between two groups were not unconspicuous (p>0.05). The adjuvant therapy of Baofukang Suppository can effectively regulate the relevant indexes of tumor cell EMT, delay or prevent the EMT of tumor cells.
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