Comparative analysis of combined oral contraceptives and non-steroidal anti-inflammatory drugs (NSAIDS) in treating dysmenorrhea: A multi-center study

Background: The incidence of dysmenorrhoea is high and mainly concentrated in young women, which seriously affects their quality of life. Objective: To compare and analyze the clinical efficacy of compounded oral contraceptives and non-steroidal anti-inflammatory drugs in the treatment of dysmenorrhoea. Methods: In a multicenter study, 120 cases of dysmenorrhea patients from People's Hospital of Xiaodian district between October 2020 and December 2023 were divided into CC group (treatment with ethinyl estradiol cyproterone tablets) and ND group (treatment with celecoxib capsules). The pain scores, sex hormone levels and clinical efficacy were mainly compared. The secondary indexes included cancer antigen 125 (CA125), osteocalcin (BGP) level, immune indexes and adverse reaction rates and recurrence rate. Results: After treatment, significant changes in the indicators of both groups was (P<0.05). The pain score, sex hormone levels, CA125 level and immune indexes in CC group were below ND group and the clinical efficacy was above ND group (P<0.05). No obvious differences were found in the BGP levels, adverse reaction rates and recurrence rates of both groups was (P>0.05). Conclusion: Both have some efficacy in the treatment of dysmenorrhoea and compound oral contraceptives were found to be more effective, which is worth promoting their use in the clinic.