REPORT: Effects of dexamethasone and atorvastatin on atrial sodium current and its early tachycardia-induced electrical remodeling in rabbits

Purpose: Atrial fibrillation (AF) results in tachycardia-induced ionic remodeling. Pharmacological prevention of tachycardia-induced ionic remodeling not only with “classical” antiarrhythmics but also with drugs which provide a basis for some of the pillars of the so-called “upstream” therapy of AF like corticosteroids or statins has been proposed as a therapeutic strategy.