Pakistan Journal of Pharmaceutical Sciences

Abstract: Background: SJAMP, a natural polysaccharide compound, has demonstrated significant inhibitory effects on various tumor models. Whether it plays a role in cervical cancer is unclear. Objectives: To explore the effects of SJAMP on the mTOR/p70S6K signaling pathway and the invasion and migration abilities of cervical cancer HeLa cells. Methods: The HeLa cells were divided into blank/solvent/polymer control groups and 1.2, 3.2 and 6.4 g/L SJAMP treatment groups. The cell proliferation, migration, invasion abilities, as well as the expression of mTOR/p70S6K protein and mRNA were detected. Results: As the concentration of SJAMP increased, the proliferation, migration and invasion abilities of HeLa cells were significantly reduced (all P < 0.05) and the protein and mRNA expressions of mTOR and p70S6K also decreased in a concentration-dependent manner (all P < 0.05). Conclusion: SJAMP can effectively inhibit the proliferation, migration and invasion of cervical cancer HeLa cells and this inhibitory effect is strongly dose-dependent and correlates with the downregulation of the mTOR/p70S6K signaling pathway.