Impact of Chitosan as a disintegrant on the bioavailability of furosemide tablets: In vitro evaluation and in vivo simulation of novel formulations

To determine the effect of chitosan, starch powder, polyvinylpyrrolidone (PVP), Avicel PH 101 powder, Avicel PH 102 granules as a function of different concentrations on the solubility, disintegration and hence dissolution of furosemide from immediate release tablet dosage forms.