Pharmacokinetics and tissue distribution study of two novel quinazoline PI3K/mTOR dual-inhibitors, potential anticancer agents

Jiangang Chen; Xiaoli Bian; Sanqi Zhang; Guangde Yang

doi:10.36721/PJPS.2023.36.5.REG.1527-1542.1

original articles

Pharmacokinetics and tissue distribution study of two novel quinazoline PI3K/mTOR dual-inhibitors, potential anticancer agents

Jiangang Chen, Xiaoli Bian, Sanqi Zhang, Guangde Yang

Vol. 36

Issue 5

Pages 1527-1542

Online Date: 01 Sept 2023

Published: 01 Sept 2023

DOI: 10.36721/PJPS.2023.36.5.REG.1527-1542.1

Authors Abstract Related

Authors & Affiliations

Jiangang Chen

Xiaoli Bian

Sanqi Zhang

Guangde Yang

Abstract

S1 and S2, two structurally similar quinazoline derivatives, are novel anticancer drugs targeting the PI3K/AKT/mTOR signaling pathway channel

Keywords

Quinazoline derivative

pharmacokinetics

tissue distribution

anticancer

HPLC

Metrics

PlumX Metrics

original articles

Pharmacokinetics and tissue distribution study of two novel quinazoline PI3K/mTOR dual-inhibitors, potential anticancer agents

Jiangang Chen, Xiaoli Bian, Sanqi Zhang, Guangde Yang

Vol. 36

Issue 5

Pages 1527-1542

Online Date: 01 Sept 2023

Published: 01 Sept 2023

DOI: 10.36721/PJPS.2023.36.5.REG.1527-1542.1

Authors Abstract Related

Authors & Affiliations

Jiangang Chen

Xiaoli Bian

Sanqi Zhang

Guangde Yang

Abstract

S1 and S2, two structurally similar quinazoline derivatives, are novel anticancer drugs targeting the PI3K/AKT/mTOR signaling pathway channel

Keywords

Quinazoline derivative

pharmacokinetics

tissue distribution

anticancer

HPLC

Metrics

PlumX Metrics

Pharmacokinetics and tissue distribution study of two novel quinazoline PI3K/mTOR dual-inhibitors, potential anticancer agents

Authors & Affiliations

Abstract

Keywords

Metrics

Indexed & Abstracted in Leading Databases

Pharmacokinetics and tissue distribution study of two novel quinazoline PI3K/mTOR dual-inhibitors, potential anticancer agents

Authors & Affiliations

Abstract

Keywords

Metrics