By: Xinyan Yan, Tian Yun, Yujie Hu, Chong Hu, Chengye Xiao, Yunrong Chen
Keywords: Different times, rt-PA thrombolysis, acute cerebral infarct (ACI), neurological function, complications.
DOI : 10.36721/PJPS.2024.37.5.REG.1119-1128.1
Abstract: This study investigates the effects of rt-PA thrombolytic therapy at varying times on neurological function and complications in acute cerebral infarction (ACI) patients. A total of 120 ACI patients admitted between August 2019 and July 2021 were divided into three groups based on the timing of rt-PA treatment: <3h (40 patients), 3–4.5h (55 patients), and >4.5h (25 patients). All received standard treatment and rt-PA IV thrombolysis. Key comparisons included cerebral oxygen metabolism, oxidative stress, neural markers, hemodynamics, coagulation function, NIHSS scores, ADL, clinical efficacy, and complications. Results showed that 48 hours post-treatment, SjvO2 levels were significantly higher in the <3h and 3-4.5h groups compared to the >4.5h group. SOD levels were also higher in the earlier groups, while MDA levels were lower. Three months after treatment, NIHSS scores were significantly lower and ADL scores higher in the <3h and 3-4.5h groups, with lower complication rates. Efficacy was similar within 3 hours and 3–4.5 hours, but complications increased significantly after 4.5 hours.
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