By: Guangjing Tao, Xiao Wang
Keywords: Qian Lie Shu Tong Jiao Nang, finasteride tablets, benign prostatic hyperplasia, real-world study.
DOI : 10.36721/PJPS.2024.37.6.REG.1591-1597.1
Abstract: With the rapid development of traditional Chinese medicine, the combination of Chinese and Western medicine for treating Benign Prostatic Hyperplasia (BPH) has been gradually promoted in clinical medical practice in China. Both Qian Lie Shu Tong Jiao Nang and Finasteride tablets are effective in treating BPH. However, there is a lack of reports on their combined use, so their efficacy and safety still need to be verified. This study explored the clinical effectiveness and safety of Qian Lie Shu Tong Jiao Nang combined with Finasteride tablets for BPH based on real-world data. Results showed that this combination significantly improved the total treatment efficiency (P<0.05) and reduced the International Prostate Symptom Score (IPSS), Chronic Prostatitis Symptom Index (NIH-CPSI), residual urine volume (RUV), tumor necrosis factor (TNF-?) and serum estradiol (E2) levels (all P<0.05). Prostate volume (PV) was notably decreased, while interleukin-10 (IL-10), serum testosterone (T) and maximum urinary flow rate (Qmax) were significantly increased (all P<0.05). The incidence of adverse reactions did not increase with the combination treatment. These observations suggest that the combined use of Qian Lie Shu Tong Jiao Nang and Finasteride tablets may more effectively alleviate BPH symptoms, improve urination functions and have a high safety profile.
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