Pakistan Journal of Pharmaceutical Sciences

Abstract: This research aims to examine the combining dexmedetomidine with lumbar plexus sciatic nerve block in elderly individuals with sustained femoral shaft fractures. 76 elderly patients were randomly divided into observation group (n=38) and control group (n=38). The anesthesia effectiveness was evaluated at multiple time points between the two groups using various factors. In different time points, diastolic blood pressure, systolic blood pressure and heart rate had significant variations in observation group compared to control group, while no difference in the occurrence of adverse reactions. Patients in observation group had a decreased need for analgesics upon awakening and at 12 and 24 hours after surgery; a lower Visual Analog Scale (VAS) score upon awakening and at 6, 12 and 24 hours post-surgery; required lower doses of anesthetics at T2, T3 and T4 time points; lower levels of interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-?) at T2 and T3 time points and higher patient satisfaction levels (all P<0.05). The combination of dexmedetomidine with lumbar plexus sciatic nerve block proves to be an effective anesthesia technique for elderly patients with femoral shaft fractures and these findings provide support for its broader implementation within clinical practice.