Therapeutic effect of levodopa-carbidopa-entacapone combined with rTMS in Parkinson's disease

Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive tissue deterioration. This study evaluated the effects of levodopa-carbidopa-entacapone (LCE) combined with high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) in elderly PD patients. Participants were divided into an observation group (HF-rTMS + LCE) and a control group (HF-rTMS alone). Motor and cognitive function, quality of life, and adverse effects were assessed before treatment and at 8 weeks, 16 weeks, and 6 months post-treatment. Both groups showed no significant differences in baseline data. However, post-treatment, the observation group demonstrated superior clinical improvements. The Unified Parkinson's Disease Rating Scale-III (UPDRS-III) score significantly decreased from 43.40±3.94 to 34.73±5.05 at 6 months (P0.05). These results suggest HF-rTMS combined with LCE enhances motor function, balance, cognition, and quality of life in elderly PD patients without increasing adverse effects.