By: Muhammad Muzammil Nazir, Muhammad Arif, Mahnoor Arif, Iqra Farzeen, Anjum Khursheed, Asma Ashraf, Hareem Noor, Muhammad Haneef, Abdulhakeem S Alamri, Majid Alhomrani, Walaa F Alsanie, Hammad Saleem
Keywords: Antidepressant, Desmostachya bipinnata, anxiety, sedative, in-silico, docking.
DOI : 10.36721/PJPS.2025.38.1.REG.279-289.1
Abstract: The purpose of this study was to assess the ethanolic extract of Desmostachya bipinnata (EEDBR)'s sedative and antidepressant properties in Swiss albino mice. The extract was given to Swiss albino mice in single doses of 100, 200 and 400mg/kg of body weight for different biological tests. In the open field test, the diazepam group and the 400mg/kg dosage group spent more time in the centre zone than the control group. The 400mg/kg dosage and diazepam group had no discernible effect on centre time response. Additionally, a dosage of 100mg/kg exhibits a significant impact of 44±3.60. Compared to treated with EEDBR, those given with standard control Diazepam (1mg/kg) had higher head dips. At all dosages, there was a substantial decrease in locomotor activity in HCT as compared to the control group at all time intervals (between 30 and 120 minutes). Diazepam, the positive control, significantly lowers locomotor activity. EEDBR reduced sadness and anxiety in a dose-dependent way. Higher dosages of EEDBR result in noticeably stronger antidepressant effects, indicating a dose-dependent connection. For the molecules isopulegone, geranyl isovalerate and eucalyptol, the in-silico docking scores for Cyclooxygenase-1 and Cyclooxygenase-2 are -8.2, -6.2, -8.4 and -8.9, -7.2, -7.6 respectively.
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