Pakistan Journal of Pharmaceutical Sciences

Abstract: To explore the application and efficacy of a combined pharmacological and behavioral intervention in the rehabilitation of children with autism, emphasizing individualized treatment approaches. Ninety-six hospitalized children diagnosed with autism, aged 3-8 years, were randomly assigned to an experimental group or a control group. The control group received conventional interventions, including systematic language training, behavioral therapy, and social interaction exercises. The experimental group received additional individualized pharmacological interventions, including anti-anxiety drugs (e.g., alprazolam) and antipsychotic medications (e.g., risperidone), with dosages tailored to each child based on age, weight and symptom severity. The efficacy of interventions was assessed using the Aberrant Behavior Checklist (ABC) alongside additional measures, including self-care ability and social communication skills. Adverse effects of medications were closely monitored and recorded. The experimental group demonstrated significant improvements in social skills and self-care ability, a marked reduction in stereotypical behaviors and a greater decrease in ABC scores compared to the control group. These improvements were achieved with manageable and well-monitored side effects. The addition of pharmacological intervention to conventional therapies provides enhanced therapeutic benefits in the rehabilitation of children with autism. This approach significantly improves core symptoms, particularly social communication and behavior management, supporting its integration into clinical practice. Further research is recommended to optimize individualized treatment protocols and evaluate long-term outcomes.