Pakistan Journal of Pharmaceutical Sciences

Abstract: This study aimed to analyze the characteristics and prognostic factors of multi-drug resistant Pseudomonas aeruginosa (MDRPA) pulmonary infection in elderly patients. Clinical data from 118 elderly patients diagnosed with MDRPA infections at Chinese PLA General Hospital were retrospectively reviewed. The 118 cases were mainly from ICU (51 cases, 43.22%) and respiratory department (30 cases, 25.42%). Among MDRPA strains isolated, resistance rates were highest for aztreonam (79.66%), ticarcillin (59.32%), and piperacillin (53.39%), and lowest for tobramycin (15.25%), amikacin (16.49%), and gentamicin (19.49%). ROC analysis highlighted ICU admission (AUC=0.718, sensitivity=73.8%, specificity=69.7%) as the strongest predictor. Logistic regression analysis showed that age ?68.5 years (P=0.022, OR=6.907, 95%CI:1.320-36.152), history of diabetes and cardiovascular disease (P=0.005, OR=4.147, 95%CI:1.526-11.274; P=0.009, OR=3.702, 95%CI:1.387-9.884) and admission to ICU (P<0.001, OR=8.097, 95%CI:3.031-21.635) were independent predictors of poor prognosis in elderly patients with MDRPA pulmonary infection. The primary departments responsible for MDRPA pulmonary infections in elderly patients were the ICU and the Respiratory Department. The resistance situation was severe, particularly for aztreonam, ticarcillin and piperacillin. Admission to ICU was a significant predictor of poor prognosis, while age, history of diabetes and cardiovascular diseases also had a notable impact on prognosis.