By: Xiaoyu Wang, Yake Sun, Qingliang Zhao
Keywords: Corneal foreign body injury; Deproteinized calf blood extract eye gel; Sodium aescinate
DOI : 10.36721/PJPS.2025.38.6.REG.14567.1
Abstract: The aim of this study was to assess the efficacy of combining sodium aescinate tablets with deproteinized calf blood extract eye gel (DCB-EG) in treating corneal foreign body injuries. This retrospective study included 270 patients divided into three groups: Combination (sodium aescinate + DCB-EG, n=90), Gel (DCB-EG, n=90) and Control (routine anti-infection, n=90). Primary outcome was clinical efficacy rate; secondary outcomes included pain scores (VAS), corneal healing metrics, inflammatory markers (IFN-?, TNF-?, IL-17), tear film stability (BUT), corneal epithelial status (CESS), tear secretion (SIt) and ocular surface disease index (OSDI). Data were analyzed using ANOVA or Chi-square test. The research results showed that the Combination group achieved the highest efficacy (98.89%), significantly better than the Gel (91.11%) and Control (86.67%) groups (P<0.05). Combined intervention shortened corneal edema resolution time, corneal healing time and pain relief time, while also reducing VAS scores and inflammatory factor levels (all P<0.05). Additionally, the Combination group demonstrated superior tear film stability, corneal epithelial repair and subjective symptom improvement compared to the Control group (all P<0.05). No significant differences in adverse events were observed (P>0.05). The combination therapy provided a safe and optimized treatment method for corneal foreign body injuries.
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