Pakistan Journal of Pharmaceutical Sciences

Abstract: Diabetes is a challenging health condition, posing a considerable financial burden. Diabetic wounds represent a significant and growing health concern worldwide, as they often fail to heal properly and pose severe consequences for diabetic patients. Hydrogels have emerged as a potential treatment for diabetic ulcers, showing promise in modern wound care. This research explores the potential of Psyllium husk (Isabagol) in the formation of a hydrogel to treat diabetic ulcers. Psyllium mucilage hydrogel was prepared, and its efficacy was assessed using various assays. The Alpha-glucosidase inhibition assay assessed its anti-diabetic activity, with extracts prepared at concentrations of 25mg/mL, 50mg/mL and 25mg/mL in PBS solvents. Additionally, the DPPH assay was used to predict the hydrogel's radical scavenging property. Results indicated that Psyllium mucilage extract demonstrated significant medicinal properties, inhibiting alpha glucosidase and scavenging free radicals produced by DPPH in a concentration-dependent manner. The highest inhibition activity was observed at 125mg/mL, with 92.75% for antidiabetic activity and 50.1% for DPPH radical scavenging. Moreover, an In vivo experiment on a mice model confirmed the hydrogel's significant wound healing activity. In conclusion, Psyllium mucilage hydrogel exhibits promising antidiabetic and anti-oxidative properties, making it a potential candidate for the treatment of diabetic wounds.