By: Huacheng Li, Weixi Zhong, Jian Sun
Keywords: C-Reactive protein; Drug resistance; Moxifloxacin; Piperacillin/tazobactam; Procalcitonin; Rate of bacterial clearance; Severe pneumonia; 30-day mortality
DOI : 10.36721/PJPS.2026.39.4.REG.15307.1
Abstract: Background: Elderly patients with severe pneumonia face elevated mortality from complex, often resistant, polymicrobial infections. Objective: This investigation aimed at assessing the efficacy and determinants of PTZ plus moxifloxacin for severe elderly pneumonia. Methods: Retrospectively, this study evaluated 120 elderly severe pneumonia patients (2021–2024), grouped by treatment: Control (n=60): IV piperacillin-tazobactam (PTZ), 4.5g q6h; observation (n=60): PTZ + daily moxifloxacin 400mg. Primary outcomes: pathogen resistance/clearance; secondary: 30-day mortality, readmission, CURB-65, ventilation duration, serum biomarkers. Logistic regression identified mortality factors; adverse events were recorded. Results: Baseline characteristics were comparable between groups (P>0.05). The observation group demonstrated superior primary outcomes (P<0.001) and pathogen clearance (P=0.013). No significant intergroup differences were found in secondary outcomes, including mortality, readmission, PLT and adverse events. Post-treatment CURB-65?3, PCT and CRP significantly correlated with 30-day mortality (all P<0.001). Conclusion: The moxifloxacin-PTZ regimen enhanced microbial clearance without affecting survival, readmission, or adverse event rates, supporting its targeted clinical use.
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